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June 16, 2025 3 min read

Magnesium is an essential mineral that plays a role in over 300 biochemical reactions in the body. From supporting muscle and nerve function to regulating blood sugar levels and aiding in energy production, magnesium plays a crucial role in overall health. Yet, despite its importance, magnesium deficiency is surprisingly common, thanks to depleted soil, processed diets, and modern stressors.

When it comes to supplementation, the variety of magnesium types—citrate, glycinate, oxide, malate, threonate—can be confusing. Not all forms are created equal. Some are better absorbed, others are gentler on the digestive system, and some are specifically designed to address particular health concerns. In this post, we’ll focus on two of the most popular and effective forms: magnesium citrate and magnesium glycinate. We’ll break down their benefits and best use cases so you can choose the one that aligns with your health goals.

Why Magnesium Matters

Magnesium plays a central role in many of the body’s most vital functions. It's especially known for its contribution to energy production (as it concentrates in muscle mitochondria, the “powerhouses” of our cells), supporting restful sleep, easing muscle tension, and promoting a healthy mood.

Despite its significance, our intake of magnesium has dropped dramatically over the past century. Today, symptoms like fatigue, irritability, muscle tightness or spasms, painful menstrual cycles, high blood pressure, poor appetite, insomnia, and sugar cravings can all be linked to magnesium deficiency.

Because magnesium is primarily found in whole foods like leafy greens, legumes, seeds, and nuts, individuals who consume a diet high in processed foods may be especially at risk. Other populations with increased need or reduced absorption include athletes, children undergoing rapid growth, and those with digestive disorders that impair nutrient absorption.

Magnesium Citrate vs. Magnesium Glycinate

While there are many forms of magnesium available, citrate and glycinate stand out for their bioavailability and effectiveness. Magnesium citrate is one of the most commonly used forms, known for its ability to relieve constipation. It is well absorbed but tends to have a laxative effect, making it less ideal for individuals who are sensitive to digestive changes or already prone to loose stools. Magnesium glycinate, on the other hand, is chelated with the amino acid glycine, which offers additional calming properties. This form is typically easier on the stomach and is often the preferred option for those looking to support sleep, cardiovascular health, muscle recovery, or mood balance. It doesn’t carry the laxative effect that citrate does, which can make it a more versatile, everyday supplement.

For many people, magnesium glycinate can effectively cover a wide range of needs—including those which magnesium citrate is often used—except relieving constipation.

How to Choose the Right Form for You

Start by identifying your primary health goals. Are you looking to improve sleep, ease anxiety, reduce muscle tension, or support cardiovascular function? Magnesium glycinate is likely your best fit. If you're dealing with chronic constipation, however, magnesium citrate may be more effective.

Magnesium is generally well tolerated, but it's always a good idea to start with a low dose and gradually increase as your body adjusts. This helps avoid digestive discomfort and gives your gut time to improve absorption.

If you've had issues with magnesium supplements in the past—especially experiences with loose stools—it’s worth noting that older forms like magnesium oxide (which is poorly absorbed) and citrate are more likely to cause this effect. Switching to a more modern, gentler form like glycinate may completely change your experience.

While magnesium has a low side effect profile, it can interact with certain medications. You should consult with a nutritionally-minded healthcare provider if you're taking diuretics, calcium supplements, antibiotics, chemotherapy, immune suppressants, asthma medications, steroids, or other laxatives. Individuals with kidney failure should only use magnesium supplements under the guidance of their nephrologist.

Final Thoughts

Magnesium may be just one mineral, but its role in your physical and mental well-being can’t be overstated. Whether you’re looking to improve sleep, reduce stress, ease muscle tension, or support overall vitality, the right form of magnesium can make all the difference. Explore Superior Labs’ clean, effective magnesium supplements—crafted without unnecessary fillers or synthetic ingredients. Choosing the right magnesium form is a small shift that could yield major benefits for your health.